新的甲基化相关候选肿瘤抑制基因-BLU
摘要
基因由于外源性修饰而失活的机制主要有三种：染色质的固缩，组蛋白的去乙酰化以及启动子的甲基化。将肿瘤抑制基因（tuinor suppressor gene,TSG）在肿瘤细胞中的失活现象与其启动子的异常甲基化相结合，已成为肿瘤学研究的一个热点。近年来在肺癌、乳腺癌、肾癌等实体肿瘤中都发现染色体3p21等位缺失频繁发生，
出处
《实验与检验医学》
CAS
2008年第5期539-540,共2页
Experimental and Laboratory Medicine
参考文献13
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