摘要
目的研究联合应用国产苯扎贝特与氟伐他汀治疗混合型高脂血症的安全性及有效性。方法选取180例混合性高脂血症患者随机分为两组，单药氟伐他汀组90例，给予氟伐他汀40mg，每晚1次，用药24周；联合治疗组90例，给予氟伐他汀40mg，每晚1次，苯扎贝特200mg，每日2次。观察24周。结果两组均能使患者低密度脂蛋白胆固醇水平较治疗前降低，差异有统计学意义（均P〈0．01），联合治疗组能够使患者甘油三酯下降，高密度脂蛋白胆固醇升高，差异亦有统计学意义（均P〈0．05）。结论联合应用氟伐他汀40mg＋苯扎贝特400mg治疗混合型高脂血症优于单用氟伐他汀治疗，并有良好的安全性。
Objective To evaluate the efficacy and safety of combination therapy with domestic bezafibrate and fluvastatin in patients with combined hyperlipidemia. Methods 180 patients with combined hyperlipidemia were randomly divided into two groups. They were assigned to receive 40 mg fluvastatin （ n = 90 ） or a combination of 400 mg bezafibrate and 40 mg fluvastatin （ n = 90 ） for 24 weeks. Results After 24 weeks treatments, the serum TC, LDL-C levels were reduced （P 〈0.01 ） and HDL-C level was increased more significantly （P 〈0.05） in the combination therapy group. Conclusion Combination therapy with bezafibrate （400 mg） and fluvastatin （40 mg） is more effective than fluvastatin （ 40 mg ） monotherapy.
出处
《中国综合临床》
北大核心
2008年第11期1086-1088,共3页
Clinical Medicine of China
基金
河北省科技攻关计划项目（0627611016）
