摘要
目的:弓形虫作为专性细胞内寄生的医学原虫在妇幼保健方面已经引起了广泛的关注,研究中药蒿甲醚在治疗弓形虫感染中的作用,为临床弓形虫感染患者特别是孕妇提供新的治疗策略。方法:建立弓形虫感染的小鼠模型,将感染弓形虫的小鼠分为两组,分别给予蒿甲醚和磺胺嘧啶钠治疗。观察各组小鼠的存活情况,并且采用PCR方法取小鼠肝脏进行检测。结果:蒿甲醚组的存活率73.3%、磺胺嘧啶钠组的存活率为60%,两种药物治疗效果差异具有统计学意义(P<0.05),蒿甲醚组治疗效果优于磺胺嘧啶钠组。结论:本研究初步探讨了蒿甲醚治疗弓形虫的理论机制,实验结果表明蒿甲醚对治疗急性弓形虫感染有一定的疗效,为蒿甲醚用于临床治疗弓形虫病提供了依据。
Objective： To explore the effects of artemether in toxoplasma infection, provide a new strategy for toxoplasma therapy. Methods： The rats models of toxoplasma gondii infection were established. The infective rats were divided into two groups, one group was treated with artemether and the other was treated with sulfadiazine sodium. Then the survival rate of infective rats was compared. Moreover, the livers of the rats were tested by PCP~ Results： The survival rate of group with artemether was 73.3% and that of the other group was 60. 0%. The effect of artemether was better than that of sulfadiazine sodium （ P 〈 0. 05） . Conclusion： Artemether is an effective drug used in toxoplasma gondii infection and this research provides useful data for clinical therapy.
出处
《中国妇幼保健》
CAS
北大核心
2008年第31期4453-4455,共3页
Maternal and Child Health Care of China
基金
天津医科大学基金项目(2005K1/61)
关键词
蒿甲醚
孕妇
弓形虫病
PCR
Artemether
Pregnant women
Toxoplasmosis
PCR
