新型联吡啶双膦配体的合成及其在β-酮酸酯不对称加氢反应中的应用

Synthesis of a New Bipyridyl Diphosphine Ligand and Its Application to Asymmetric Hydrogenation of β-Keto Esters

合成了新型联吡啶手性双膦配体(R)-MeO-P-Phos[(R)-2,2',6,6'-四甲氧基-4,4'-二(二(对甲氧基)苯基膦基)-3,3'-联吡啶)],并将其用于β-酮酸酯不对称加氢反应.考察了不同溶剂对反应的影响,在乙醇中对乙酰乙酸乙酯加氢可获得99.1%的对映选择性;新配体对含不同取代基的β-酮酸酯同样表现出非常高的活性和对映选择性.

A new electron-donating diphosphine （R）-MeO-P-Phos [（R）-2,2＇,6,6＇-tetramethoxy-4,4＇-bis[di- （4-methoxylphenyl）phosphino]-3,3＇-bipyridine] has been synthesized and its application to the asymmetric hydrogenation of β-keto esters catalyzed by ruthenium complex was explored. Solvent effect was tested and up to 99.1% ee was achieved for the hydrogenation of ethyl acetoacetate in EtOH. The asymmetric hydrogenation of various β-keto esters catalyzed by Ru-MeO-P-Phos was investigated.