射频消融治疗胰腺肿瘤安全性的临床研究

Clinical study on safety of radiofrequency ablation for pancreatic tumors

目的:探讨射频消融治疗胰腺肿瘤的安全性。方法:回顾性分析2002年1月-2007年12月对78例不能切除胰腺肿瘤的患者行射频消融治疗发生的并发症资料。结果:所有患者均有短期发热症状,部分患者有一过性血清淀粉酶升高,无腹腔出血及腹腔感染发生,胰瘘2例,上消化道出血1例,血管并发症2例,急性重症胰腺炎1例,术后总并发症发生率为7.69%(6/78),其中死亡3例,发生率为3.85%(3/78)。结论:对于不能切除的胰腺肿瘤射频治疗是安全可行的,但由于可能出现致命性严重并发症,必须慎重。

Objective： To evaluate the safety of radiofrequency ablation （RFA） for unresectable pancreatic tumors. Methods ： During January 2002 to December 2007,78 patients with unresectable pancreatic tumor were treated by open cool-tip RFA. Clinical records of complications were retrospectively studied. Results： Temporary fever occurred in all patients, and transient elevated blood anylase occurred in part of patients, and no celiac bleeding and no celiac abscess. The incidence of post-operation complications was 7.69% （6/78）, and the mortality was 3.85% （3/78）. In the 6 cases, two were pancreatic leakage, one was upper gastrointestinal bleeding, one was acute severe pancreatitis, and the other two were vassular complications. Conclusion： Radiofrequency ablation for unresectable pancreatic tumors is generally safe and feasible. However, it may cause severe and life-threatening complications. The management of RFA must be prudent and careful.