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Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data 被引量:1

Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
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摘要 Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully. Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully.
出处 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2008年第2期111-120,共10页 基因组蛋白质组与生物信息学报(英文版)
基金 National Science Councilunder contract NSC-93-2213-E-390-002.
关键词 reverse engineering system modeling genetic programming recurrent neural network expression data reverse engineering, system modeling, genetic programming, recurrent neural network, expression data
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