紫杉醇联合奈达铂与顺铂联合5氟尿嘧啶/亚叶酸钙治疗晚期食管癌对比研究

Comparative study of clinical effects between paclitaxel plus nedaplatin and cisplatin plus 5-fluorouracil/calcium folinate in advanced esophageal cancer

目的观察紫杉醇联合奈达铂(TN方案)与顺铂联合5氟尿嘧啶/亚叶酸钙(PLF方案)治疗晚期食管癌的近期疗效和毒副反应。方法将48例晚期食管癌随机分为A、B两组。A组24例应用TN方案,B组24例应用PLF方案,两方案均以21d为1周期。至少化疗两个周期方可评价疗效和毒副反应。结果TN方案有效率54.1%,PLF方案有效率29.2%;两组共同的毒副反应为骨髓抑制,TN组轻度肌肉关节疼痛发生率较高(75%),PLF组消化道毒副反应、肾损害发生率较高。结论TN方案治疗晚期食管癌有效率高于PLF方案,毒副反应可耐受。

Objective rio compare the rrecent effect and side effect of the two regiment between paclitaxel plus nedaplatin（TN） and cisplatin plus 5-fluorouracil / calcium folinate（PLF） in advanced esophageal carcinoma. Methods A total of 48 patients with advanced esophageal cancer were divided into group A and group B randomly. Group A were treated with TN and group B with PLF regiment for 21 days as a cicle. The side ef- feet were evaluated after 2 cicles. Rusults The effective rate in the group A and B was 54.1% and 29.2% respectively. With the common side effect of myelosuppression in two groups. The incidence rates of arthralgia in group A were more higher, and gastrointestinal reaction, renal damage were higher in group B. Conelution TN regiment for advanced esophageal cancer were more effective than PLF regiment and well tolerated.