心房颤动患者血浆C反应蛋白水平变化的临床研究

Changes of concentration of plasma C-reactive protein in patients with atrial fibrillation

目的探讨C反应蛋白(CRP)在心房颤动(AF)的发生与维持中的变化从而了解其相关性。方法对32例阵发性AF患者分别于发作时及终止后1周、26例持续性AF患者分别于发作时及发作2周时测外周静脉血浆CRP浓度,与30例同期住院体检者作对照,进行统计学分析。结果AF组患者AF发作时血浆CRP浓度(阵发性AF组16.8±5.1mg/L、持续性AF组21.1±5.9mg/L)比正常对照组(2.3±1.1mg/L)明显升高,P<0.01,且升高持续至AF终止后1周或持续发作2周时;在AF组中,持续性AF组CRP浓度显著高于阵发性AF组,P<0.01。结论CRP增高反映的炎症状态可能与AF的发生与持续性密切相关。

Objective To explore changes of C-reactive protein （CRP） and its relationship to atrial fibrillation （AF）. Methods The immunochemistry method was used to determine the serum CRP concentration in 32 paroxysmal AF patients and 26 persistent AF. Levels of plasma CRP were compared to levels in 30 control healthy subjects. Results Serum CRP level of patients with AF 16.8±5.1 mg/L was higher than that in control group 2.3±1.1 mg/L,P〈0.01 ,serum CRP level of persistent AF 21.1± 5.9 mg/L is higher than paroxysmal AF （16.8±5.1） mg/L,P〈0.01. Conclusions The inflammatory state of high CRP level may promote the occarrence and persistence of AF.