肾病综合征患者尿蛋白和血白蛋白浓度与血脂异常的关系

Relationship between Proteinuria or Serum Albumin Level and Lipid Abnormalities in Patient with Nephrotic Syndrome

为研究原发性肾病综合征时大量蛋白尿和低白蛋白血症与脂质代谢异常之间的关系，检测20例住院原发性肾病综合征病人24h尿蛋白排泄量、血白蛋白浓度、血总胆固醇及低密度脂蛋白浓度。结果发现，肾病综合征病人都有明显的脂质代谢异常，尿蛋白量和血总胆固醇浓度呈正相关（r=0．43，P＜0．05），和低密度脂蛋白有一定相关，但无统计学意义（r＝0．37，P＞0．05）；血白蛋白浓度和血总胆固醇及低密度脂蛋白均呈明显负相关（分别为r=-0．69，P＜0．01及r=-0．51，P＜0．01）。提示，肾病综合征时蛋白尿和低白蛋白血症与脂质代谢异常存在明显的相关关系。

Aim To investigate the relationship between heavier proteinuria or hypoalbuminemis and serum lipid abnormalities in primary nephrotic syndrome.Methods Serum albumin, total cholesterol (TC),low density lipoprotein cholesterol (LDLC) and 24-hour urinary protein content were assayed in nephrotic syndrome patients (n=20) and healthy controls (n=20).Results Hyperlipidemia is a consistent feature of the nephrotic syndrome patients. 24-hour urinary protein content was positive correlated with the level of serum TC (r=0. 43, P<0.05), but no statistically significance was observed between proteinuria and serum LDLC (r =0. 37, P >0.05). The level of serum albumin was inversely significantly correlated with both the level of serum TC and LDLC (r=-0.69, P<0. 01, r=-0. 51, P<0. 01, respectively).Conclusion There were correlated relationship between proteinuria or hypoalbuminemia and serum lipid abnormalities in nephrotic syndrome.