CagA^+幽门螺杆菌感染的慢性萎缩性胃炎与中医证型的关系研究

Relationship between TCM Syndrome-type and Chronic Atrophic Gastritis Infected by H.pylori with CagA Gene

目的:通过前瞻性描述性调查性临床研究,了解CagA+幽门螺杆菌(H.pylori)感染的慢性萎缩性胃炎(CAG)与中医证型的关系。方法:将31例经血清学分型诊断为CagA+H.pylori感染的CAG患者,按照中医辩证方法分为脾胃湿热、肝胃不和、脾虚湿热、脾虚气滞及脾胃虚寒证五型,同时观察患者的年龄、性别、病程、病情及H.pylori分级与中医证型之间的关系。结果:(1)31例中脾胃湿热证(29%)和脾虚湿热证(41.9%)共占总数的一半以上(,2)CagA+H.pylori感染的CAG患者性别和病情轻重与中医证型显著相关(均为P<0.05)。结论:CagA+H.pylori感染的CAG总体以实证和虚实夹杂证为主,尤以湿热因素多见。CagA+H.pylori感染引起的CAG中性别与中医证型之间有一定关联,胃黏膜病变程度与中医证型亦有关联性。

Objective： To study the relationship between TCM syndrome-type and chronic atrophic gastritis（CAG） infected by H.pylori with CagA gene. Methods： The syndromes of thirty-one patients diagnosed CAG by serum diagnostic were analyzed. According to the differentiation of syndromes, these patients were divided into five TCM syndrome-types： dampness-heat in both spleen and stomach type, disharmony between liver and stomach type, dampness-heat in deficient spleen type, spleen deficiency with obstruction of Qi type, and deficiency-cold of both spleen and stomach type. The relationship of age, gender, period of diseases, state of illness, classification of H.pylori and five TCM syndrome-types was observed as well. Results： （1） The proportion of the dampness-heat in both spleen and stomach type （29%） and dampness-heat in deficient spleen type （41.9%） are more than 50% altogether. （2）In CAG infected by H.pylori with CagA gene there was significant relationship between gender and state of illness and five TCM syndrome-types （P〈0.05）. Conelusion： The TCM syndrome-type of CAG infected by H.pylori with CagA gene are mostly caused by dampness heat factor. There is some relationship between gender as well as the degree of pathological change of gastric mucosa and TCM syndrome-type.