摘要
目的:研究野八角Illicium simonsii乙醇粗提物中显示抗艾滋病毒活性部位的化学成分。方法:应用各种色谱技术进行分离纯化,用MS和NMR分析鉴定化合物结构。结果:从野八角90%乙醇提取物的抗艾滋病毒活性部位分离得到7个化合物,分别鉴定为(+)-儿茶精(1),(-)-表儿茶精(2),(+)-儿茶精3-O-α-L-鼠李糖苷(3),山柰素3-O-α-L-鼠李糖苷(4),槲皮素3-O-α-L-鼠李糖苷(5),3,5-二甲氧基-4-羟基苯甲酸-7-O-β-D-吡喃葡萄糖苷(6)和胡萝卜苷(7)。结论:以上7个化合物均为首次从该植物中分离得到,化合物3,6是首次从该属植物中发现,但均未显示抗艾滋病毒活性。
Objective: To study the chemical constituents from the active fractions against HIV in vitro, a crude ethanolic extract of lllicium simonsii. Method: The compounds were isolated with column chromatography methods. MS and NMR spectroscopic methods were used to determine the structures of the compounds. Result: Seven compounds were isolated from the active fractions against HIV in vitro of the 90% ethanol extract and their structures were elucidated as ( + )-catechin (1), ( - )-epicatechin (2), ( + ) -catechin 3-O-α-L-rhamnopyranoside ( 3 ), kaempferol 3-O-α-L-rhamnopyranoside ( 4 ), quercetin 3-O-α-L-rhamnopyranoside (5), erigeside C (6) and daucosterol (7). Conclusion: Seven compounds were isolated from this plant for the first time, but none of them exhibited active against HIV in vitro. Compounds 3 and 6 were isolated from this genus for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第21期2490-2492,共3页
China Journal of Chinese Materia Medica
基金
北京市教委面上项目(KM200811417009)
关键词
野八角
抗艾滋病毒活性
化学成分
lllicium simonsii
anti-HIV activity
chemical constituents