野八角化学成分的研究

Studies on chemical constituents of Illicium simonsii

目的:研究野八角Illicium simonsii乙醇粗提物中显示抗艾滋病毒活性部位的化学成分。方法:应用各种色谱技术进行分离纯化,用MS和NMR分析鉴定化合物结构。结果:从野八角90%乙醇提取物的抗艾滋病毒活性部位分离得到7个化合物,分别鉴定为(+)-儿茶精(1),(-)-表儿茶精(2),(+)-儿茶精3-O-α-L-鼠李糖苷(3),山柰素3-O-α-L-鼠李糖苷(4),槲皮素3-O-α-L-鼠李糖苷(5),3,5-二甲氧基-4-羟基苯甲酸-7-O-β-D-吡喃葡萄糖苷(6)和胡萝卜苷(7)。结论:以上7个化合物均为首次从该植物中分离得到,化合物3,6是首次从该属植物中发现,但均未显示抗艾滋病毒活性。

Objective： To study the chemical constituents from the active fractions against HIV in vitro, a crude ethanolic extract of lllicium simonsii. Method： The compounds were isolated with column chromatography methods. MS and NMR spectroscopic methods were used to determine the structures of the compounds. Result： Seven compounds were isolated from the active fractions against HIV in vitro of the 90% ethanol extract and their structures were elucidated as （ ＋ ）-catechin （1）, （ - ）-epicatechin （2）, （ ＋ ） -catechin 3-O-α-L-rhamnopyranoside （ 3 ）, kaempferol 3-O-α-L-rhamnopyranoside （ 4 ）, quercetin 3-O-α-L-rhamnopyranoside （5）, erigeside C （6） and daucosterol （7）. Conclusion： Seven compounds were isolated from this plant for the first time, but none of them exhibited active against HIV in vitro. Compounds 3 and 6 were isolated from this genus for the first time.