晕痣和痣细胞痣bcl-2蛋白的表达

Expression of bcl 2 in Tissues from Halo Nevus and Melanocytic Nevus

为了研究细胞凋亡在晕痣发生中的作用，我们对８例晕痣和８例痣细胞痣患者皮损进行了ｂｃｌ－２原癌基因产物（Ｂ－ｃｅｌｌｌｙｍｐｈｏｍａ／ｌｅｕｋｅｍｉａ２ｇｅｎｅｐｒｏｄｕｃｔ，以下简称ｂｃｌ－２）的免疫组化观察。结果表明８例晕痣均见有ｂｃｌ－２的阳性表达，８例痣细胞痣仅有３例表达ｂｃｌ－２，而且染色明显较弱，大部分组织呈阴性表达。由于两种痣ｂｃｌ－２表达明显不同，作者认为晕痣组织内ｂｃｌ－２的过量表达与晕痣发生的自身免疫机制有关。

In order to study the role of apoptosis on halo nevus development, we studied the expression of bcl 2 in 8 patients with halo nevus and 8 patients with melanocytic nevus using immunohistochemical methods. All 8 patients with halo nevus and 3 of 8 patients with melanocytic nevus expresed bcl 2, but the staining was significantly weaker in the patients with melanocytic nevus. Because the expression of bcl 2 was obviously different in the tissues of the two types of nevus, the authors believe that the over expression for bcl 2 may be related to the autoimmune mechanism of halo nevus development, and it may be a homeostatic response to high rate of apoptosis in the tissues of halo nevus.