原发性高血压患者血浆内皮素、一氧化氮和D-二聚体的检测及临床意义分析

A study on plasma ET,NO and DD level of essential hypertension(EH)patients

目的检测原发性高血压(essential hypertension,EH)患者血浆内皮素(ET-1)、一氧化氮(NO)和D-二聚体(DD)的水平变化及分析其临床意义。方法选取94例原发性高血压患者作为研究对象,以62例健康人作为止常对照。分别采用放射免疫法测定血浆内皮素水平,硝酸还原酶法测定血浆一氧化氮水平和散射免疫比浊法测定D-二聚体水平,并进行统计学分析。结果与正常对照相比较,原发性高血压患者血浆ET—1和DD水平明显升高(P<0.01),而NO水平则降低(P<0.01);经过治疗之后患者血浆ET-1和DD水平降低(P<0.01),而NO水平升高(P<0.01)。结论血浆ET-1、NO和DD联合检测,能够较好地反映原发性高血压患者的病情及进展,为其早期治疗和预测发展趋势提供重要依据。

Objective To investigate the concentration of plasma ET-1, NO and DD in essential hypertension （EH） patients and controls. Methods In our study, plasma ET-1, NO and DD level was measured by radioimmunity, nitrate rednctase assay, and nephelometric immunoassay, respectively. Results Plasma level of ET-1 and DD in EH group was higher than that in eontroi group （P 〈0.01） , and NO level in EH group was lower than that in control group （ P 〈 0.01 ）. The level of ET-1 and DD in EH patients has fallen off （ P 〈 0. 01 ） and NO level has increased （ P 〈 0.01 ） after therapy. Conclusion Significant difference in plasma ET-1, NO and DD level was observed between EH group and control group, and it may play a very important role in the development of hypertension.