高血压病患者颈动脉内膜中层厚度的相关研究

The Influencial Factors of Carotid intimal medial Thickness in Essential Hypertension

目的分析高血压病患者颈动脉内膜中层厚度的影响因素。方法高血压病患者246例,通过两种分组方法,1.根据颈动脉内膜中层厚度(IMT,mm),分为IMT1(IMT≤0.8),IMT2 (0.8<1MT<1.2),IMT3(IMT≥1.2)三组,2.根据糖尿病状况分为三组,高血压无糖尿病组(组1)、高血压伴糖耐量减低组(组2)、高血压伴糖尿病组(组3),分析IMT与年龄、收缩压、脉压、高血压病程、体重指数、血脂、尿酸、平均心率、空腹血糖的相关性,结果1.IMT1,IMT2及IMT3三组间的体重指数、即测血压、高血压病程、总胆固醇、甘油三酯、低密度脂蛋白、空腹血糖及血尿酸水平均无显著性差异;2.IMT与年龄、收缩压、脉压相关(P<0.001);3.高血压无糖尿病组患者空腹血糖与IMT呈正相关。结论高血压病患者IMT与年龄、脉压密切正相关;无糖尿病的高血压患者空腹血糖可能与IMT正相关。

Objective To analyze the influential factors of Carotid intimal medial thickness in essential hypertension. Methods According to the IMT（mm）measured by color Doppler ultrasound, 246 hypertensive patients were divided into three following groups： IMTI （IMT ≤ 0.8） , IMT2 （0.8 〈 1MT 〈 1.2） , IMT3 （ IMT≥ 1.2） , Moreover, all the patients were divided into three groups groupl （ hypertensive without diabetes）, group2 （ hypertensive with IGT ）, group3 （ hypertensive with diabetes ）. The correlation between IMT and BMI, blood pressure ,pulse pressure ,history of hypertension, age , average heart rate ,blood fat, blood uric acid（UA） and fasting plasma glucose （FPG） ,etc was analyzed. Results 1. There was no significant difference of BMI, history of hypertension, average heart rate , blood fat, UA and FPG among IMT1, IMT2 and IMT3. 2. The differences of age ,blood pressure ,pulse pressure among IMT1,1MT2 and IMT3 were sig- nificant（P 〈0. 001 ）. 3. The FPG was in positive correlation with 1MT in groupl. Conclusion The IMT is tightly in positive correlation with age and pulse pressure in hypertensive patients . The FPG may be in positive correlation with IMT in hypertensive patients without diabetes.