化妆品接触性皮炎的发病机理探究

Discussion on Mechanism of Contact Dermatitis Induced by Cosmetics

分别讨论了变应性接触性皮炎(allergic contact dermatitis,ACD)和刺激性接触性皮炎(irritant contact dermatitis,ICD)的发病机理。ACD是由T淋巴细胞介导的抗原特异性皮肤过敏反应,以抗原刺激后局部皮肤出现一系列的皮肤炎症细胞浸润、炎症介质释放为特征,属于迟发IV型变态反应,而ICD是不产生特异性抗体的皮肤炎症;防腐剂、香料香精、乳化剂是引起化妆品接触性皮炎致敏物的三类主要致敏源,并讨论了人们对化妆品接触性皮炎认识的几个误区。

In this paper, pathogenesis for allergic contact dermatitis （ACD） and irritant contact dermatitis （ICD） were dis cussed respectively. ACD is an antigen-specific skin allergies mediated by T cells with the characteristics of delayed hypersensi tivity IV. In the process of ACD, a series of infiltration of inflammatory cells and the release of inflammatory mediators will ap pear after stimulated by allergen. ICD is another kind of skin inflammation without specific antibody. Antiseptic, flavor fra grance and cosmetics emulsifier are the three major sources of allergens causing contact dermatitis. Some misunderstandings a bout the cosmetic contact dermatitis were also discussed in the paper.