甲酸甲酯与三聚甲醛偶联合成乙醇酸甲酯 Ⅰ.硫酸催化反应条件优选

Synthesis of methyl glycolate by coupling of methyl formate with trioxane I. Study of optimum reaction conditions with sulphuric acid as catalyst

研究了硫酸催化甲酸甲酯（ＭＦ）与三聚甲醛偶联合成乙醇酸甲酯的反应，考察了甲酸甲酯与甲醛的摩配比、硫酸用量、反应温度、反应时间对收率的影响，优选出反应最佳条件：反应温度１００℃、三聚甲醛１２ｇ、ＭＦ４５ｍｌ、Ｈ２ＳＯ４１０ｍｌ、反应时间４ｈ。在此反应条件下得到乙醇酸甲酯收率３６．２０％和甲氧基乙酸甲酯收率２４．１０％的结果。

Methyl formate (MF) is coupled with trioxane to synthesize methyl glycolate(MG) over a sulphuric acid catalyst.The effects are studied of the ratio of HCHO/MF (mol/mol), amount of sulphuric acid, reaction temperature and time on the product yield. The reaction conditions optimized are t =100℃, (HCHO) 3=12g, MF=45 ml, H 2SO 4=10ml, and time=4h, under which the yields of methyl glycolate and methyl methoxyacetate obtained are 36.2% and 24.1% , respectively.