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脂联素对糖尿病大血管病变的影响 被引量：1

Effect of adiponectin on diabetic macro-angiopathy
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摘要 脂联素(adiponectin,APN)是脂肪细胞分泌的一种细胞因子,通过结合APN受体1和受体2发挥抗炎、抗糖尿病、抗动脉粥样硬化的作用。1型糖尿病病人和正常人的血清APN水平相似,但2型糖尿病病人的APN水平显著降低。2型糖尿病的心血管并发症明显增加,且2型糖尿病合并心血管病变患者的APN水平明显低于2型糖尿病但无心血管病变者,提示糖尿病大血管病变可能与APN缺乏有关。 Adiponectin （APN） is an adipocyte secreting cytokine, which exerts anti-inflammatory, anti-diabetic,and anti-atherosclerotic effects via combining with adiponectin receptor-1 and 2. The se- rum adiponectin concentration is similar between type 1 diabetes and normal, but significantly decreased in type 2 diabetes. Cardiovascular complications are evidently augmented in patients with type 2 diabetes. APN levels are significantly lower in cases of cardiovascular diseases combined with type 2 diabetes than those without type 2 diabetes, suggesting that macro-vascular lesions may be related to the lack of APN. Illustrating the mechanism of APN effect on macro-vascular may contribute to provide a new idea that macro-angiopathy is less in type 1 diabetes compare to type 2 diabetes, even though fluctuate in a large range. glucose
作者 董源媛 肖新华
机构地区 南华大学附属第一医院内分泌科
出处 《国际病理科学与临床杂志》 CAS 2008年第5期452-455,共4页 Journal of International Pathology and Clinical Medicine
基金 湖南省自然科学基金(07JJ6160) 湖南省卫生厅课题(2007117)~~
关键词 脂联素 脂联素受体 糖尿病 大血管病变 adiopnectin adiopnectin receptor diabetes macrovascular
分类号 R587.1 [医药卫生—内分泌]
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参考文献21

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二级参考文献1

共引文献4

同被引文献76

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国际病理科学与临床杂志
2008年 第5期

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