动态监测降钙素原对脑出血患者感染及预后判断的意义

Clinical significance of dynamic determination of serum procalcitonin levels in judgement of infection and prognosis in patients with brain hemorrhage

目的:探讨动态监测血清降钙素原(PCT)对脑出血患者感染及预后判断的临床意义。方法:对入住重症监护病房的重度脑出血患者42例在入院第1、2、3、5、7天分别采集静脉血标本检测血清PCT值,以判断PCT水平变化与脑出血患者感染及预后之间的关系。结果:合并感染组与非感染组相比各时段血清PCT明显升高,差异有显著性(P<0.01)。以入院第10天为界将合并感染患者分为存活组与死亡组,其中存活组与死亡组各时段PCT水平比较存在统计学差异。结论:动态监测血清PCT的水平变化可以作为判断脑出血患者感染及预后的有效指标之一。

Objective To explore the clinical significance of dynamic determination of serum procalcitonin （PCT） levels in judgement of infection and prognosis in patients with brain hemorrhage. Methods Serum PCT levels were deteeted in 42 patients with severe brain hemorrhage on the first, second, third, fifth, and seventh day of admission in intensive care unit. The association of the changes of PCT and infection in the patients and their prognosis was analyzed. Results Serum PCT levels in the concurrent infection group were significantly higher than those in the non-infection group at different time points（P 〈 0.01 ）. The patients with concurrent infection were subdivided into survival group and death group on the tenth day. PCT levels at different time points differed significantly between the two subgroups. Conclusions The alteration of serum PCT level may be used as one of the effective predictors for infection in patients with brain hemorrhage and for their prognosis.