摘要
目的探讨早期应用醛固酮受体拮抗剂-螺内酯干预对急性心肌梗死患者室性心律失常的影响。方法通过观察急性心肌梗死患者93例,年龄43～82岁,对49例急性心肌梗死患者在常规治疗的基础上加用螺内酯40mg/d(螺内酯组),对照组(n=44)常规治疗。在6个月干预期内检测两组24h动态心电图室性心律失常发生率。结果治疗6个月时螺内酯组与对照组相比室性心律失常发生率有明显降低。结论急性心肌梗死患者常规治疗基础上早期加用小剂量醛固酮受体拮抗剂——螺内酯治疗后可减少室性心律失常的发生。
Objective To investigate the effect of spironolactone on arrhythmias in patients with acute myocardial infarction. Methods 93 AMI eases were randomly divided into spironolactone group（n=49）,and routine treatment group（n=44）. All patients were examined by halter on the 1st week,3rd and 6th month. Results After 6-month intervention,the spironolaetone group had a lowered ventricular arrhyflunias compared with control group（P〉 0.05 ）. Conclusion These findings indicate that in patients with AMI, spironolactone combined with routine treatment can prevent ventricular arrhythmias.
出处
《中国现代医生》
2008年第30期69-70,共2页
China Modern Doctor
关键词
急性心肌梗死
螺内酯
心律失常
Acute myocardial infarction
Spironolactone
Arrhythmias
