AgNOR在淋巴结良恶性病变中的诊断价值

DIAGNOSTLC VALUE DF AgNORs IN BENIGNAND MALIGNANT PATHOLOGIC CHANGES OF LYMPH NDDES

目的：观察AgNOR在淋巴结良恶性病变中的差异。方法：分别抽取慢性淋巴结炎、淋巴结反应性增生、恶性淋巴瘤病理标本各12、17、28例。参照Ploton改良方法。观察比较嗜银颗粒的数量、形态及分布情况。结果：恶性淋巴瘤组中瘤细胞核内AgNOR颗粒平均4～7个，大小不一，散在分布于核内，形态不规则。而慢性淋巴结炎及反应性增生组中，细胞核内AgNOR颗粒平均1～2个，大小较一致，多居核中。结论：淋巴结良恶性病变中，细胞核内嗜银颗粒无论在数量、大小、形态及分布上都有显著差异，故AgNOR可用于二者的鉴别诊断。

Objective To observe the differences of AgNORs in benign and malignant pathologic changes of lymph nodes. Methods:Here withdrawn respectively were pathologic specimens of 12 cases of chronic lymphnoditis. 17 cases of reactive hyperplasia of lymph nodes,and 28 cases of malignant lymphoma. The quantity. appearance and distribution of the argentaffin granules were compared, referring to the improved method of Ploton. Results AgNORs granules in the oncocyte nuclei of malignant lymphoma averaged 4 to 7,scattered wiside the nuclei with irregular appearance, while AgNORs granules in the nuclei of chronic lymphnoditis and reactine hyperplasia averaged 1 to 2,mostly located in the middle of the nuclei with approximately the same size. Condusions There are significant differences in the quantity, appearance and distribution of argentaffin granules in theuclei between benign and malignant pathologic changes of lymph nodes. and tharefore AgNORs can be applied in the differential diagnosis of both benign and malignant changes flymph nodes.