中风患者超氧化物歧化酶及血栓烷/前列环素相关性临床研究

Clinical Research on Correlation between SOD and TXB_2/6-k-PGF_(lα) in Stroke Patients

目的探讨中风患者超氧化物歧化酶(SOD)和血栓烷/前列环素(TXB2/6-k-PGFlα)的相关性及其与中医证型之间的关系。方法对74例中风患者和36例健康对照者分别测定其全血SOD含量和血浆TXB2、6-k-PGFlα水平,分析二者间的相关关系及与中医证型的关系。结果中风患者全血SOD含量较对照组显著降低(P<0.01),且与神经功能缺损积分之间存在明显负相关关系(r=-0.53)。中风患者血浆TXB2水平和TXB2/6-k-PGFlα值较对照组均显著增高(P<0.01)。中风患者血浆TXB2水平与神经功能缺损积分之间存在明显正相关关系(r=0.61)。结论血浆TXB2水平和TXB2/6-k-PGFlα值的增高可作为中风"血瘀"辨证的客观化指标之一。

Objective To research the correlation between SOD and TXB2/6-k-PGF1α and relationship with TCM syndrome in stroke patients. Methods A contrast test on blood SOD and plasma TXB2 and 6-k-PGF1α was given separately to two groups, one group was 74 cases with stroke and the control group was 36 cases in health. Results Content of blood SOD in stroke group reduced remarkably compared with the health group （P〈0.01）. There was a negative correlation （r =-0.53） between blood SOD and the degree of dysfunction of CNS. Level of plasma TXB2 and TXB2/PGF1α in stroke group increased remarkbly compared with the health group （P〈0.01）. There was a positive correlation （r =0.61） between plasma TXB2 and the degree of dysfunction of CNS. There was a negative correlation （r =-0.47） between blood SOD and plasma TXB2 in stroke group. Conclusion The increase of the level of plasma TXB2 and TXB2/PGF1α can be regarded as one of the objective indexes in idenfying blood stasis syndrome of stroke.