更年降脂方治疗更年期综合征合并高脂血症的临床研究

Clinical Research of Gengnianjiangzhi Prescription on Treating Perimenopausal Syndrome Combined with Hyperlipemia

目的:观察更年降脂方治疗更年期综合征合并高脂血症的疗效。方法:将符合纳入标准的60例更年期综合征,按1∶1随机分为治疗组(更年降脂方)和对照组(利维爱)。治疗前后进行改良Kupperman症状(K)评分、中医证候评分,并检测内分泌激素水平(E2、FSH)和血脂水平(TC、TG、LDL-C、HDL-C),以及阴道出血、乳胀等不良反应。结果:治疗4周、8周时,治疗组和对照组K评分、中医证候评分较治疗前均有显著下降(P<0.05),两组组间比较差异无显著性意义(P>0.05)。两组E2水平在治疗8周时与治疗前相比,差异均无显著性意义(P>0.05);两组FSH、TC、TG、LDL-C、HDL-C水平治疗8周时与治疗前相比,差异有显著性意义(P<0.05),但组间比较差异无显著性意义(P>0.05)。结论:更年降脂方改善更年期综合征合并高脂血症患者临床症状和调节激素水平及血脂水平,作用与利维爱相当,安全性好。

Objective： To evaluate the curative effect of Gengnianjiangzhi prescription on treating perimenopausal syndrome combined with hyperlipemia. Methods：60 cases of perimenopausal syndrome were divided randomly into the treatment group （treated by Gengnianjiangzhi prescription） and the contrast group （treated by Livial） with same cases each group. The improved Kupperman syndrome （K） score, the traditional Chinese medical symptom and sign （TCMSS） score was evaluated before and after therapy. The level of endocrine hormone （ E2 and FSH） and the level of blood fat （TC, TG, LDL-C and HDL-C） were examined. The side effect such as vagina bleeding and breast swelling was observed. Results： The K score and the TCMSS score of the treatment group and the contrast group was obviously reduced after 4 and 8 weeks of therapy （ P 〈 0.05 ）. The difference between two groups had no significant meaning （ P 〉 0.05） The difference of E2 level of two group before therapy and 8 weeks after therapy had no significant meaning （ P 〉 0.05 ）. The level of FSH, TC, TG, LDL-C and HDL-C in each group was obviously varied before therapy and 8 weeks after therapy （ P 〈 0.05 ）. The difference between two groups had no significant meaning （ P 〉 0.05 ）. The difference of two groups on the safety index has no significant meaning. However, there was no cased of side effect in the treatment group and three cases of vagina bleeding and on cases of side effect in the contrast group. Conclusion： Gengnianjiangzhi prescription has the same effect of Livial on improving the clinical symptom of perimenopausal syndrome combined with hyperlipemia, regulating the level of hormone and blood fat. Gengnianjiangzhi prescription is also safer and has less side effect than Livial.