益肺调血汤对变应性鼻炎大鼠血清白介素水平的影响

Effect of Yifei Tiaoxue Decoction on Serum Interleukin Levels in Rats with Allergic Rhinitis

目的:观察益肺调血汤对实验性变应性鼻炎(AR)大鼠血清白介素(IL)水平的影响,以探讨其治疗机制。方法:采用二异氰酸甲苯酯(TDI)对大鼠进行实验性AR造模,50只大鼠随机分为正常组、模型组、辛芩颗粒组、益肺调血汤高剂量组、益肺调血汤低剂量组,每组10只。灌胃治疗2周后处死大鼠,腹主动脉取血,检测血清中IL-2、IL-4水平的变化。结果:模型组的IL-2水平明显下降,IL-4水平则明显上升,与正常组比较,差异均有非常显著性意义(P<0.01);益肺调血汤各剂量组IL-2及IL-4水平与正常组比较,差异均无显著性意义(P>0.05)。辛芩颗粒组IL-2及IL-4水平与模型组比较,差异有非常显著性意义(P<0.01);IL-4水平与正常组比较,差异无显著性意义(P>0.05)。结论:益肺调血汤可能是通过调节AR大鼠血清白介素水平而对AR产生治疗作用的。

Objective:To observe the effect of Yifei Tiaoxue Decoction(YTD) on serum interleukin levels in rats with allergic rhinitis(AR)and to explore its thera- peutic mechanism.Methods:AR rat models were induced by toluene diisocyanate. Fifty rats were equally randomized into 5 groups:normal group,model group,Xinqin Granules group,low-dose and high-dose YTD groups.After treatment for 2 weeks,the changes of serum interleukin 2 and interleukin 4 levels were observed. Results:Serum IL-2 level was decreased,and serum IL-4 level increased in the model group,the difference being significant as compared with the normal group(P<0.01).The differences of serum IL-2 and IL-4 levels between YTD groups and the normal group were insignificant(P>0.05).Serum levels of IL-2 and IL-4 in Xinqin Granules group differed from those in the model group,but the difference of IL-4 Level was insignificant between Xinqin Granules group and the normal group(P>0.05).Conclusion:The therapeutic mechanism of Yifei Tiaoxue Decoction for AR may be related with regulation of serum interleukin levels.