大黄对尿毒症非透析患者微炎症和氧化应激状态的影响

Effects of Rhubarb against Microinflammation and Oxidative Stress Status in Nondialysed Patients with Uremia

目的:观察大黄对尿毒症非透析患者微炎症和氧化应激状态的疗效。方法:尿毒症非透析病人47例,随机分为观察组和治疗组,治疗组给予大黄泡服2月。并设健康对照组。治疗前及治疗2月后检测血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)以及血浆丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)水平。结果:与对照组相比,观察组和治疗组hs-CRP、TNF-α、IL-6和MDA水平均明显升高(P<0.01);GSHPx水平下降(P<0.01)。治疗2月后治疗组hs-CRP、TNF-α、IL-6和MDA水平均明显下降,GSHPx水平增高,与观察组相比有显著性差异。结论:大黄可以改善尿毒症非透析患者微炎症和氧化应激状态。

Objective To investigate the efficacy of rhubarb on microinflammation and oxidative stress status in nondialysed patients with uremia. Methods Forty-seven nondialysed patients with uremia were randomly allocated to observation group and treatment group, another 20 healthy volunteers were served as control group. Patients in treatment group were administered with infused decotion of rhubarb for 2 months. The blood levels of high sensitivity C-reactive protein（hs-CRP） ,tumour necrosis factor-α （ TNF-α）, interleukin-6 （ IL-6 ）, malonaldehyde （ MDA ） and glntathione peroxidase （ GSHPx ） were measured before and after the treatment, respectively. Results Compared with control group, the levels of hs-CRP, TNF-α, IL-6 and MDA in both observation group and treatment group before therapy were significantly increased （P 〈 0.01, respectively）, the concentration of GSHPx was significantly decreased（ P 〈 0.01 ）. The levels of hs-CRP, TNF-α, IL-6 and MDA after therapy were significant lower than those before treatment（ P 〈 0.01, respectively）, and the concentration of GSHPx after therapy was significant higher than that before therapy（ P 〈 0.01 ）. There were a significant difference on these indexes between treatment group and observation group after treatment. Conclusion Rhubarb eould effectively improve mieroinflammation and oxidative stress status in nondialysed patients with uremia.