环氧合酶2在膀胱移行细胞癌中的表达及意义

Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof

目的探讨环氧合酶2（COX-2）在膀胱移行细胞癌中的表达及临床意义。方法采用免疫组织化学法对56例膀胱移行细胞癌组织及10例正常膀胱组织进行COX-2检测。结果10例正常膀胱组织均未见COX-2表达。56例肿瘤组织中，COX-2阳性率为55．36％。COX2表达与肿瘤的分级分期呈高度正相关（P〈0．01）。结论COX-2的表达与膀胱移行细胞癌的分级分期有密切的关系。

Objective To study the expression of cyclooxygenase-2 （COX-2） in bladder transitional cell carcinoma （Tcc） and the clinical significance thereof. Methods Immunohistochemistry was used to detect the expression of COX-2 in 56 specimens of bladder Tcc and 10 specimens of normal bladder tissue, all resected during operation. Results No expression of COX-2 was detected in the 10 specimens of normal bladder tissue and in the 56 specimens of bladder Tcc the positive rate of COX-2 was 55.36%. The expression of COX-2 in bladder Tce was closely correlated with the grade and stage of tumor （ both P 〈 0.01 ）. Conclusion COX-2 expression in bladder Tcc is closely correlated with the grade and stage.