胃肠道间质瘤同时性肝转移的同期手术切除

Simultaneous resection of gastrointestinal stromal tumour primary neoplasm and synchronous liver metastases

目的探讨同时性胃肠道间质瘤（gastrointestinal stromal tumor，GIST）肝转移行同期切除原发肿瘤和肝转移瘤的于术疗效。方法回顾性分析7例GIST同时性肝转移同期于术病人的临床资料。结果7例病人中男5例，女2例；中位年龄52（43～67）岁。原发肿瘤部位分布为：胃2例，小肠5例。拿组接受手术切除，无明星并发症，l例病人术后2个月死于肝内复发，1例术后8个月肝内复发者服用伊马替尼，肿瘤进展得到控制。其余病人在随访1年期间未见肿瘤复发或转移。结论同期手术切除对于合适的同时性GIST肝转移瘤病人安全、有效。

Objective To assess the therapeutic effect of simultaneous resection of gastrointesti hal stromal tumor （GIST） primary neoplasm and synchronous liver metastases. Methods Seven patients who underwent simultaneous resection of GIST primary neoplasm and synchronous liver metastases were identified and their clinicopathological data were analyzed retrospectively. Results There were 5 males and 2 females. The median age was 52 years （43 67 years）. The distribution of primary neoplasm location included 2 cases in the stomach and 5 in small bowel. All patients received surgical resection without complications. One patient died 2 months after surgery because of recurrent fiver disease. One patient received imatinib for remnant recurrent liver disease 8 months after surgery and the disease progression was controlled. Other patients remained alive and well without recurrence or metastases during the follow-up for 1 year. Conclusion Simultaneous resection is safe and effective for selected patients with synchronous GIST liver metastases.