磁性氟尿嘧啶白蛋白微球抗人胰腺癌的实验研究

Inhibitory effects of 5-fluorouracil magnetic albumin microsphere on human pancreatic carcinoma

目的研究磁性氟尿嘧啶白蛋白微球（5-fluorouracil magnetic albumin microspheres，5-FU-MAMS）联合恒定外磁场体内外对人胰腺癌的生长抑制作用。方法体外培养人胰腺癌PC-3细胞及建立裸鼠人胰腺癌模型，磁场作用下，观察5-FU—MAMS体内外对人胰腺癌的生长抑制作用。结果5-FU-MAMS在外加磁场的磁导向作用下，体外5-FU-MAMS能显著抑制肿瘤细胞生长，与其它组比较，抑制率（IR）明显提高（P〈0．05）；体内5-FU—MAMS能很好的定位于肿瘤组织并显著抑制肿瘤生长，肿瘤体积抑制率达到90．47％，肿瘤重量抑制率达到88．16％，与其它组比较，差异有统计学意义（P〈0．01）。结论在磁场作用下，5-FU—MAMS作为靶向药物治疗胰腺癌能够取得良好的效果。

Objective To investigate the inhibiting effects of 5 fluorouracil magnetic albumin microsphere （5-FU-MAMS） in combination with constant external magnetic fields on human pancreat ic carcinoma in vitro and in vivo. Methods The human pancreatic carcinoma PC 3 cells were cultured and an experimental model was established in nude mice to investigate the inhibiting effects. Results In vitro study showed that 5-FU-MAMS in combination with constant external magnetic fields could significantly inhibit the growth of PC 3 cells as compared with other agents （P〈0.05）. The in vivo study revealed that 5-FU-MAMS could be well localized in the tumor tissue and markedly inhibit the growth of tumor. The inhibitory rate of tumor size was 90. 47% and that of tumor weight 88. 16%. There were significant differences as compared with other groups （P〈0.05）. Conclusion Under constant external magnetic fields, 5-FU-MAMS can achieve satisfactory results for targeted therapy of pancreatic carcinoma.