重症哮喘β_2受体激动剂不同吸入方法疗效的比较

Comparison of Different Methods of β_2-agonists Inhalation in Severe Asthma

本文观察了30例重症哮喘患者β_2受体激动剂不同吸入方法的疗效.30例患者随机分成A组10例(定量气雾剂吸入组Salbutamol 300μg吸入),B组10例(低浓度雾化吸入组Salbu-tamol 5mg吸入)和C组10例(高浓度雾化吸入组Salbutamol 10mg吸入).吸入前、后分别观察PEFR、呼吸频率和心率.结果提示,在重症哮喘治疗中,应用定量雾化剂组疗效不佳,但雾化吸入组疗效均较明显而持久,尤以高浓度组产生疗效更快而且副作用亦不明显.治疗中应用面罩式氧气雾化器.其应用方便既能保证吸入的雾量.又能保证供氧.作者认为,在重症哮喘的治疗中,雾化吸入β_2受体激动剂是解除支气管严重痉挛的最快捷的方法之一,应在重症哮喘救治中常规使用.

The results of three different methods of inhalation in 30 patients with severe asth-ma were of served. These patients were divided randomly into three groups. Group A inhaled300pg of salbutamol using the metered dose inhaler (MDI). Group B inhaled 5mg of salbutamolusing low dose nebulizator. Group C inhaled 10mg of salbutamol using high dose nebuliator. PE-FR, the rate of the breathing and the heart rate before and after inhalation were also of served.The results showed that MDI had no effect on treating severe asthma. The nebulization of salbuta-mol was very effective to severe asthma in both groups. PEFR in group C improved more thanthat in group B, but there was no difference of the rate of the breathing and the beart rate betweengroup B and group C.We consider that nebulization of salbutamol is an effective method for the treatment of severasthma.