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胰岛素样生长因子及其I型受体抗体对人肾上腺皮质癌SW-13细胞凋亡的调控 被引量：1

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摘要 目的探讨胰岛素样生长因子及其I型受体抗体对人肾上腺皮质癌SW-13细胞凋亡的调控和其可能机制。方法原位凋亡(TUNEL)法检测胰岛素样生长因子及其I型受体抗体单独或联合作用于SW-13细胞后细胞的凋亡的情况,同时观察细胞形态及数量的变化。结果各组细胞凋亡率比较有显著统计学差异(P<0.001),其中单用IGF-I组或IGF-II组细胞凋亡率低于空白对照组低于混合作用组低于单用anti-IGF-IR组,而单用IGF-I组和IGF-II组、IGF-I+anti-IGF-IR组和IGF-II+anti-IGF-IR组组间比较无统计学差异(P>0.05)。加入anti-IGF-IR组细胞形态也发生了明显的变化。结论胰岛素样生长因子可促进SW-13细胞株的生长,这与其抑制了细胞凋亡有关,而这种生物学作用是通过胰岛素样生长因子I型受体介导,胰岛素样生长因子I型受体抗体可明显抑制这种生物学作用,可能在肾上腺皮质癌的治疗中发挥重要作用。
作者 沈文 冼江 胡卫列 杨传红 夏冰
机构地区 广州军区广州总医院泌尿外科 南方医科大学研究生学院 广州军区广州总医院医学实验科
出处 《南方医科大学学报》 CAS CSCD 北大核心 2008年第10期1900-1902,共3页 Journal of Southern Medical University
关键词 肾上腺肿瘤 生长调节素类 细胞培养 细胞凋亡
分类号 R736.6 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1沈文,冼江,胡卫列,刘俊,刘佳.胰岛素样生长因子及其I型受体抗体对人肾上腺皮质癌SW-13细胞株体外生长的影响[J].南方医科大学学报,2007,27(1):88-91. 被引量：2
  • 2Mantero F, Albiger N. A comprehensive approach to adrenal incidentalomas [J]. Arq Bras Endocrinol Metabol, 2004, 48(5): 583-91.
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二级参考文献7

  • 1Mantero F,Albiger N.A comprehensive approach to adrenal incidentalomas[J].Arq Bras Endocrinol Metabol,2004,48(5):583-91.
  • 2Leroith D,Roberts CT Jr.The insulin-like growth factor system and cancer[J].Cancer Lett,2003,195:127-37.
  • 3David WA,Mariana N,Adam EF,et al.Results of a PILOT study involving the use of an ntisense oligodeoxynucleotide directed against the insulin-like growth factor type 1 receptor in malignant astrocytomas[J].J Clin Oncol,2001,19(8):2189-200.
  • 4Hassan AB,Macaulay VM.The insulin-like growth factor system as a therapeutic target in colorectal cancer[J].Ann Oncol,2002,13(3):349-56.
  • 5Mitsiades CS,Mitsiades NS,McMullan CJ,et al.Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma,other hematologic malignancies,and solid tumors[J].Cancer Cell,2004,5(3):221-30.
  • 6Bohula EA,Playford MP,Macaulay VM.Targeting the type 1 insulinlike growth factor receptor as anti-cancer treatment[J].Anticancer Drugs,2003,14(9):669-82.
  • 7Fottner C,Hoeflich A,WolfE,et al.Role of the insulin like growth factor system in adrenocortical growth control and carcinogenesis[J].Horm Metab Res,2004,36:397-405.

共引文献1

同被引文献26

  • 1程文超.囊性肾癌9例诊治体会[J].新医学,2004,35(12):738-739. 被引量：5
  • 2廖银花,贺修胜.RNA干扰研究进展[J].现代生物医学进展,2007,7(5):773-776. 被引量：5
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  • 5Rojas A,Liu G,Coleman I,et al.IL-6 promotes prostate tumorigen-esis and progression through autocrine cross-activation of IGF-ⅠR[J].Oncogene,2011,30(20):2345-2355.
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  • 8Cao Z,Liu LZ,Dixon DA,et al.Insulin-like growth factor-Ⅰin-duces cyclooxygenase-2 expression via PI3K,MAPK and PKC sig-naling pathways in human ovarian cancer cells[J].Cell Signal,2007,19(7):1542-1553.
  • 9Granado M,Martin AI,Villanua MA,et al.Experimental arthritisinhibits the insulin-like growth factor-Ⅰaxis and induces musclewasting through cyclooxygenase-2 activation[J].Am J Physiol En-docrinol Metab,2007,292(6):E1656-E1665.
  • 10Stoeltzing O,Liu W,Fan F,et al.Regulation of cyclooxygenase-2(COX-2)expression in human pancreatic carcinoma cells by theinsulin-like growth factor-Ⅰreceptor(IGF-ⅠR)system[J].Canc-er Lett,2007,258(2):291-300.

引证文献1

二级引证文献5

南方医科大学学报
2008年 第10期

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