小儿慢性消化系统疾病与食物原特异性IgG检测的临床分析

Detection of Food-specific Serum IgG to Food Allergens in Children with Chronic Digestive Diseases

目的探讨小儿慢性消化系统疾病与检测血清中14种食物过敏原特异性IgG的关系。方法选择慢性消化系统疾病患儿69例,其中包括排除器质性病变的慢性腹痛和反复呕吐3个月以上的患儿,久治不愈的慢性腹泻和厌食伴生长发育迟缓的患儿。使用酶联免疫法检测血清中14种食物特异性IgG水平。结果69例患儿中有68例食物过敏原特异性IgG升高,总阳性率为98.55%。食物过敏原特异性IgG升高有1到9种不等,2种以上升高的为86.96%。食物特异性IgG升高以鸡蛋92.8%和牛奶73.9%最多见,其次为小麦、大豆分别为40.6%、27.5%,鸡肉和猪肉均为0。根据试验结果调整所有患儿的饮食,病人症状在4周内明显改善的为58.46%,症状有所改善的26.15%,无效15.38%,总有效率为84.61%。随访结束后患儿症状明显改善有70.70%,症状有所改善为18.46%,无效为10.76%,总有效率为89.23%。结论测定14种食物过敏原特异性IgG在小儿慢性消化系统疾病诊治过程中有重要指导意义。

Objective To assess the value of 14 common food allergens specific IgG in children with chronic digestive diseases. Methods The specific allergen food IgG was measured by utilizing enzyme-linked immunosorbent assay （ELISA） in 69 children with chronic digestive diseases, who had chronic abdominal pain and recurrent vomiting above three months with no organic disorders, incurable chronic diarrhea and anorexia with failing to thrive. Results The food allergen specific IgG increased was detected in 68 cases. The positive cases were 98.55% . There was one to nigh kind of food allergen specific IgG increased in 68 patients. Positive above two kind of specific IgG was 86.96%. The most specific IgG was to egg 92.8% and milk 73.9% ;the other rates were： wheat 40.6% ,soybean 27.5%. Chicken and pork were negative. All the patients changed their daily diet according to the assay results. More than 58.46% cases improved with their symptoms significantly in four weeks, about 26.15% cases improved to some extent. 15.38% cases did not improved. After followed four months, there were 70.70% cases improved with their symptoms significantly, 18.46% cases improved to some extent, only 10.76% cases no improved. Conclusion The detection of 14 common food allergens specific lgG might be significant valuable in assessment and treatment children with chronic＇digestive diseases.