食管鳞癌的年龄分布与性激素受体表达变化的相关研究

Association of age distribution of esophageal squamous cell carcinoma with expressed alterations of sex hormone receptors

目的:探讨食管鳞癌的年龄分布与ER、PR表达的关系。方法:采用免疫组织化学(ABC)法,检测142例高发区青年(72例)与中老年(70例)食管鳞癌手术切除标本ER和PR的表达。结果:ER、PR阳性率在青年和中老年组中分别为51%、44%和3%、34%,两组ER阳性率间差异无统计学意义,P>0.05;PR阳性率间差异有统计学意义,P<0.05。青年组表达定位以细胞质为主,中老年组表达定位以细胞核为主。青年组ER、PR共阳性3%,共阴性74%,ER与PR表达无一致性(P>0.05)。中老年组ER、PR共阳性24%,共阴性41%,ER与PR表达具有一致性,P<0.05。ER阳性率随年龄增大而递减,差异有统计学意义,P<0.05;在各年龄组ER表达率男女性患者之间差异无统计学意义,P>0.05。结论:性激素及其受体的变化可能是食管癌变的重要机制,并与食管癌的年龄分布有关,ER可能是食管癌内分泌治疗的靶点。

OBJECTIVE： To explore the relationship between the expressions of estrogen and progesterone receptors in esophageal squamous cell carcinoma and age distribution. METHODS： The immununohistochemical method （ABC） was used to determine the expressions of ER and PR of esophageal squamous cell carcinoma （SCC） from the young patients （≤40 years old, n=72） and the elderly patients （〉40 years old, n 70） in a high incidence area for esophageal cancer. RESULTS： The immunostaining positive rates for ER and PR in the young patients and old patient were 51%, 44%（P〉0.05） and 3%, 34%（P^0.05）,respectively. The location of ER and PR expressions in the young patients was in nuclear and the location of ER and PR expressions in the old pa tient was in the cytoplasm. In the young patients, the immunostaining both positive rate for ER and PR was 3 % ,both negative rate for ER and PR was 74%, the immunoreactive of ER was not coincident with PR, P〉0.05. In the old patients, the immunostaining both positive rate for ER and PR was 24%,both negative rate for ER and PR was 41%,the immunoreactive of ER was not coincident with PR, P〈0.05. The older of the patients, the less of the immunostaining positive rates for ER, P〈 0.05. The immunostaining positive rates for ER in male and female EC patients were not significantly different in every age group, P〉0.05. CONCLUSIONS： The alteration of sex hormones and the expressions of sex hormone receptors may be one of the important mechanisms for esophageal carcinogenesis, and may be associated with age distribution for esophageal cancer. ER may be a target of endocrine therapy for esophageal cancer.