反应停抗肿瘤作用机制及临床应用的研究进展

Research progress of the anti-tumor mechanism and clinical application of thalidomide

目的:了解反应停抗肿瘤的作用机制及其在临床上的应用,为进一步研究提供参考。方法:回顾近年来国内外有关反应停抗肿瘤治疗的作用机制及临床试验文献资料。结果:反应停通过抑制肿瘤的血管生成、促使肿瘤细胞凋亡和免疫调节活性发挥抗肿瘤作用,现已作为抗肿瘤药广泛用于研究各种进展期恶性肿瘤的疗效观察。结论:大多数的研究证实反应停单用或联合地塞米松对多发性骨髓瘤有显著的活性。与其他的化疗药物或生物制剂联合应用时,对Kaposi's肉瘤、肾细胞癌和前列腺癌显示出良好的应用前景。

Objective：To review anti-tumor mechanism of thalidomide and its clinical application in order to provide basis for further research.Methods：The results of thalidomide used for clinical trials and its mechanism reported in recent years were reviewed.Results：Thalidomide used widely for treating several kinds of malignant tumor in progression phase,and its mechanisms included anti-angiogenic along with pro-apoptotic properties and immunomodulatory activity.Conclusion：Many studies have conformed the significant activity of thalidomide as well as combination with dexamethasone in treating multiple myeloma.Studies in curing Kaposi＇s sarcoma,renal cell carcinoma and prostate cancer appear more promising especially when thalidomide is combined with biological agents or chemotherapy.