基质金属蛋白酶-9和S100B蛋白与脑出血

Matrix Metallopotreinase-9, S100B Protein and Intracerebral Hemorrhage

基质金属蛋白酶（MMP）-9与脑出血后脑水肿、炎症反应、细胞凋亡等病理生理学过程密切相关。S100B作为特异性脑源性蛋白，不同的剂量水平可呈现不同的生理或病理学效应，其浓度能反映中枢神经系统损伤程度。文章对MMP-9和SIOOB在脑出血中的作用机制进行了综述。

Matrix metalloproteinase （MMP） -9 is closely correlated with the pathophysiological processes of cerebral edema, inflammatory reaction and apoptosis after intracerebral hemorrhage. As a specific brain-derived protein, the different levels of S100B may present different physiological and pathological effects. Its concentration can reflect the degree of central nervous system damage. This article reviews the action mechanisms of MMP-9 and S100B in intracerebral hemorrhage.