摘要
目的研究急性脑梗死患者血清神经元特异性烯醇化酶（NSE）水平的变化，并探讨其在急性脑梗死诊断及预后评估中的临床价值。方法选取临床确诊的47例急性脑梗死病例及同期同年龄组体检健康者30例。用电化学发光免疫分析技术（ECLIA）测定血清中NSE浓度。根据脑卒中患者临床神经功能缺损程度评分标准对患者入院时及入院三周后状态进行评分，作为预后分级标准。应用SSPS11．5软件包进行统计学处理。结果患者组NSE血清浓度与对照组间存在统计学差异（P〈0．01）。急性期和恢复期患者也存在显著性差异。血清NSE水平与脑梗死体积和预后之间存在相关性（P〈0．01）。结论急性脑梗死患者血清NSE水平明显增高，且其增高程度能够为中枢神经系统受损程度提供定量信息。并可作为预后评估的重要参数。
Objective To investigate the changes of neuron specific enolase （NSE） concentration in serum of patients with acute cerebral infarction（ACI）and to evaluate its clinical significance in ACI＇s diagnosis and prognosis. Methods 47 patients with acute cerebral infarction and 30 nomal were included in the study. Electrochemiluminescence immunoassay （ECLIA）was used to measure the serum NSE levels. All patients were scorded according to criteria of the Clinical Neurological Function Deficient （CNFD）and classified by the mark. Comparison analyze were performed by using a PASS 11.5 statistical package. Results The serum NSE levels in ACI patients were significantly higher than the normal group, and there was significant difference between acute cerebral infarction group and recovery cerebral infarction group. There was positive correlation of NSE levels with the infarction volume and prognosis （P 〈 0.01 ）. Conclusion The levels of serum NSE remarkably increased in the patients with ACI, and the increasing degree may provide quantitative information for the damage of central nervous systerm, it＇s also an important parameter of assessing the prognosis.
