摘要
目的:探讨不同周期的新辅助化疗对Ⅲ期乳腺癌近期疗效、毒性反应及保乳率的影响。方法:243例Ⅲ期乳腺癌患者接受5-氟尿嘧啶+环磷酰胺+表阿霉素(CEF方案)进行新辅助化疗(NAC)。其中141例完成2个周期化疗,102例完成4个周期化疗,对两组的近期疗效(包括肿瘤大小与化疗疗效)、毒性反应及保乳率进行比较分析。结果:NAC2周期组的总有效率为61.0%(86/141),其中临床完全缓解(CR)27例,部分缓解(PR)59例,无变化(NC)55例。保乳率为27.66%(34/141)。4周期组的总有效率为66.7%(68/102),CR25例,PR43例,NC34例,保乳率为34.31%(37/102)。两组均无进展病例。两组间化疗毒性反应比较,4周期组重于2周期组。结论:对Ⅲ期乳腺癌用CEF方案进行NAC,在肿瘤大小、化疗疗效等近期疗效上,2周期组与4周期组无显著差异;不良反性反应,4周期组重于2周期组;保乳率,4周期组优于2周期组。
Objective： To analyze retrospectively the short-term efficacy, toxicity and the rate of breast conserving operation between two different cycles neo-adjuvant chemotherapy in the treatment of stage Ⅲ breat cancer. Methods： A total of 243 patients with stage Ⅲ breast cancer were qiven neo-adjuvant chemotherapy with 5-FU CTX ＋ E-ADM（CEF） regimen. Among them, 141 patients had finished 2 cycles chemotherapy and 102 patients had finished 4 cycles. The included tumor size and chemotherapic effect, toxicity and the rate of breast conserving operation between 2 groups were analyzed. Results： NAC 2 cycles regimen produced a total response rate 61.0%（86/141）. In all of them, cCRwere27 cases,cPR were 59 cases,NC55 were cases. the rate of breast conserving operation was 27.66o/00 （34/141）. Four cycles regimen produced a total response rate was 66.70% （68/102）, including cCR 25 cases,ePR 43 cases, NC 34 cases. The rate of breast conserving operation was 34.31%（37/ 102）. Two regimen had no progressive cases all. Four cycles regimen group was heavier than 2 cycles regimen at chemothera- peutic toxicity. Conclusion： As CEF regimen used in the neo-adjuvant chemotherapy of stage Ⅲ breat cancer, at the side of short-term efficacy included tumor size and chemotherapic effect, there was no significant difference between 2 cycles regimen and 4 cycles. But at the toxicity reaction, 4 cycles regimen was heavier than 2 cycles. As for the rate of breast conserving operation, 4 cycles regimen was better than 2 cycles.
出处
《中国临床医学》
北大核心
2008年第5期717-718,共2页
Chinese Journal of Clinical Medicine
