阿奇霉素治疗婴幼儿细菌性肺炎临床观察

Clinical evaluation of injection azithromycin in the treatment of the acute bacteria pneumonia of infant

目的观察阿奇霉素治疗婴幼儿急性细菌性肺炎的有效性与安全性。方法采用开放随机对照试验方法，以红霉素作为对照药物，比较研究阿奇霉素治疗婴幼儿急性细菌性肺炎的临床疗效和安全性。结果阿奇霉素组的痊愈率和总有效率分别为75．5％和90．6％，不良反应发生率为9．3％；而红霉素组的痊愈率和总有效率分别为36．0％和68．0％，不良反应发生率为30．4％。两组比较，差异均有统计学意义（均P〈0．05）。结论阿奇霉素治疗婴幼儿急性细菌性肺炎，方便、安全、有效。

Objective To evaluate the clinical efficacy and safety of injection azithromycin in the treatment of the acute bacteria pneumonia of infant. Methods A randomized controlled open trial was carried out. Erythromycin as a controll drug was compared the clinical efficacy and safety with azithromycin as a test drug. Results In azithromycin group,the clinical effective rate was 90. 6% ;the fully recovered rate was 75. 5%. While those of erythromycin group were 68.0% ,36.0% respectively. The incidence of adverse reaction was 9. 3% and 30. 4% respectively in two groups. Conclusion Injection azithromycin of new macrolides type is a kind of effective and safe anti-bacterial drug.