化疗联合热疗治疗非小细胞肺癌临床观察

Clinical observation of the chemical and heat treatment in treating non-small-cell lung cancer

目的观察化疗联合热疗治疗中晚期非小细胞肺癌（NSCLC）的疗效和毒副反应。方法47例中晚期NSCLC患者，全部采用HP方案化疗3个周期。热疗组（24例）化疗第1天始给予热疗，热疗每周2次，每周期共4次；对照组（23例）：只给予化疗，方法同上，不热疗。观察两组患者近期疗效和毒副反应。结果热疗组疗效（11／24；45．8％）优于对照组（8／23，34．8％），但差异无统计学意义（P〉0．05）；不同病理类型比较，两组腺癌有效率（46．2％，25．0％）比较，差异有统计学意义（P〈0．05）。毒副反应热疗组轻于对照组，但差异无统计学意义（P〉0．05）。结论化疗联合热疗治疗中晚期NSCLC，患者完全可以耐受，近期疗效较单纯化疗有一定的提高，特别是腺癌热疗效果好。

Objective To observe the curative and poison side effect of the chemical and heat treatment in treating the middle and late period NSCLC. Methods There are forty-seven middle and late patients, all of them for three weeks by using the Hp plan. The heat treatment group（24） ：on the first day,the patients use the heat treatment twice a week,four times a period; the comparision group（23 ） ：give them the chemical treatment by using the same method, but dont give them the heat treatment. To observe the recent treatment effect and the poison side effect. Results The heat treatment group is better than the comparision group. But it doesn＇t have the statistic sisnificance（P 〉 0.05 ）, then we observe the pathology, the effect of the glandular cancer in heat treatment group （46.2%） is better than the eomparision group（25.0% ） （P 〈0.05）. The poison side effect mostly depends on the first and second degree. The heat treatment group is better than the comparision group. But it has no statistic significance （ P 〉 0.05 ）. Conclusion The chemical and the heat treatment to treat the middle and late NSCLC, the patients completly support （bear）. The recent treatment effect is better than the single chemical effect. Especially the effect of the glandular cancer is the best by using the heat treatment.