正电子断层显像联合薄层CT在肺小结节诊断中的价值探讨

Clinical value of ^18F-FDG PEL CT scan in the diagnosis of thin lung nodules

目的探讨18氟脱氧葡萄糖正电子断层显像（PET）联合薄层CT扫描对诊断肺小结节的临床价值。方法56例肺内孤立性小结节（直径为1～3cm）患者，行PET／CT显像和薄层CT扫描，PET显像采用目测法结合半定量法判断病灶良恶性；薄层CT扫描后再行MPR重建，根据病灶形态学特征判断良恶性；综合分析两者结果，并与术后病理结果对照比较。结果PET显像、薄层CT扫描、两者联合诊断肺小结节的灵敏度分别为92．6％、88．2％、96．4％，特异性分别为73．3％、57．1％、85．7％，准确率分别为89．3％、80．4％、94．6％，阳性预测值分别为92．6％、91．8％、96．4％，阴性预测值分别为84．6％、61．5％、92．3％。结论PET联合薄层CT扫描是临床上诊断肺小结节良恶性非常有效的方法。

Objective To investigate the clinical value of 18 F-FDG PET CT scan in the diagnosis of thin lung nodules. Methods 56 solitary cases of nodules in the lungs,nodule size ranged from 1 - 3 cm, conducted 18 F- FDG PET/CT imaging and thin layer CT scan at the same time, 18 F-FDG PET imaging using visual measurement combined with semi-quantitative method to determine the degree of malignant of the lesions ; conducted MPR reconstruction after thin layer CT scan, based on the lesions morphology to determine the degree of malignant. Then compared the results of above, and the results of the combination of 18 F-FDG PET imaging and thin layer CT scan,with the pathological results after surgery. Results The sensitivities of PET imaging alone,thin layer CT alone,joint imaging diagnosis of SPN are 92.6% ,88.2% ,96.4% ,specificity are 73.3% ,57.1% ,85.7% ,accuracy percentage rate are 89. 3% ,80. 4% ,94. 6% ,the positive predictive values are 92.6% ,91.8% ,96. 4% ,and negative predictive values are 84. 6% ,61.5% ,92.3% ,respectively. Conclusion 18 F-FDG PET combined with thin layer CT scanning is a very effective method to clinical diagnosis the malignant degree of SPN.