吡格列酮对2型糖尿病患者血浆内皮素和一氧化氮水平的影响

Effect of Pioglitazone on Endothelin and Plasma of Nitric Oxide in Type 2 Diabetic Mellitus Patients

目的:探讨吡格列酮对2型糖尿病(T2DM)患者血浆内皮素(ET)、一氧化氮(NO)的影响。方法:70名T2DM患者,随机双盲分为安慰剂组(A组,35例)和吡格列酮组(B组,35例),治疗3个月后,检测两组患者服药前后空腹血糖(FBG)、空腹胰岛素(FINS)、糖基化血红蛋白(HbA1C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、ET和NO,并计算胰岛素敏感指数(ISI)。结果:治疗后吡格列酮组FBG、FINS、HbA1C、TG、ET明显下降(P<0.01),HDL-C、ISI、NO显著升高(P<0.01),ET与FINS呈正相关(r=0.478,P<0.01),与ISI呈负相关(r=-0.306,P<0.01),NO与FINS呈负相关(r=-0.371,P<0.01),与ISI呈正相关(r=0.447,P<0.01);安慰剂组各参数于治疗前后无显著性差异。结论:吡格列酮能够显著降低T2DM患者的ET水平,升高NO水平。

Objective:To study the effects of pioglitazone on endothelin(ET)and nitric oxide(NO)of plasma in type 2 diabetic mellitus(T2DM)patients.Method:T2DM patients(n=70)were divided into placebo group(n=35)and pioglitazone group(n=35)by the rule of random and double-blind.Before and after 3 months treatment,fasting blood glucose(FBG),fasting insulin(FINS),HbA1c,triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),ET and NO were measured.The insulin sensibility index(ISI)was calculated.Results:In pioglitazone group,the levels of FBG,FINS,HbA1C,TG,ET were significantly decreased and the values of HDL-C,ISI and NO were markedly increased(P<0.01)after treatment.The ET value had positive correlation with the FINS(r=0.478,P<0.01)and negative correlation with the ISI(r=-0.306,P<0.01).The NO value had negative correlation with the FINS(r=-0.371,P<0.01)and positive correlation with the ISI(r=0.447,P<0.01).In placebo group,there were no significant differences in the levels of FBG,FINS,HbA1C,ISI,TG,HDL-C,ET,NO before and after treatment.Conclusion:Pioglitazone could significantly reduce ET and increase NO in T2DM patients.