婴肝合剂灌肠联合西药治疗婴儿肝炎综合征的临床研究

Effect of Yinggan mixture enema combined with western medicine on infantile hepatitis syndrome

目的:观察婴肝合剂灌肠联合西药治疗婴儿肝炎综合征(IHS)的临床疗效。方法:选择180例婴儿肝炎综合征患儿,随机分为西药常规治疗对照组(简称对照组)、婴肝合剂口服组(简称口服治疗组)、婴肝合剂灌肠组(简称灌肠治疗组)3组,分别采用单纯西药常规疗法、婴肝合剂口服联合西药常规疗法、婴肝合剂灌肠联合西药常规疗法。结果:灌肠治疗组,治愈52例,好转4例,无效4例,总有效率为93.3%;口服治疗组,治愈48例,好转6例,无效6例,总有效率为90%;对照组,治愈35例,好转13例,无效12例,总有效率为80.0%;临床综合疗效,灌肠治疗组与对照组组间比较,差异有非常显著性意义(P<0.01),口服治疗组与对照组比较,差异有显著性意义(P<0.05);同时,婴肝合剂联合西药治疗,能显著降低患儿血清TBil、DBil、ALT、TBA、ALP、GGT值及血清NO值(P<0.01),与对照组比较,差异有非常显著性意义(P<0.01),并能促进CMV(巨细胞病毒)转阴。结论:治疗婴儿肝炎综合征,中西医结合疗法临床疗效优于单纯西药疗法,且中药采用灌肠给药途径优于口服给药。

Objective： To evaluate the clinical therapeutic effect of Yinggan mixture enema combined with western medicine in infantile hepatitis syndrome （IHS） . Methods： One hundred and eighty cases of IHS were divided randomly into conventional control group （CCG）, oral treatment group （OTG）, and enema group （EG） . The conventional treatment of taking western medicines simply, taking Yinggan Mixture orally combined with western medicine, taking retention-enema of Yinggan mixture combined with western medicine were adopted respectively. Results： There were 52 cases were cured, 4 cases that were improved and 4 cases were invalid in EG （total efficiency was 93.3% ） . Forty eight cases were cured, 6 cases were improved and 6 cases were invalid in OTG （total efficiency was 90. 0% ） . Thirty five cases were cured, 13 cases were improved and 12 cases were invalid in CCG （ total efficiency was 80. 0% ） . The difference between EG and CCG about comprehensive clinical efficiency was very significant （P 〈 0. 01 ） . The difference between OTG and CCG about comprehensive clinical efficacy was notable （P 〈 0. 05） . Meanwhile, by taking Yinggan mixture orally combined with western medicine, the serum levels of TBil, DBil, ALT, TBA, ALP, GGT, NO were declined. There was a significant difference between OTG and CCG （P 〈0. 01 ） . Furthermore, it could promote CMV negative. Conclusion： The clinical efficiency of combining traditional Chinese and western medicine treatment is better than that of simply western medicine and the Chinese herbal enema administration is better than the oral administration.