组合化学技术中的组合合成与群集筛选

New Techniques of Combinatory Chemistry of Combinatory Synthesis and Mass/Library Screening

本文叙述了组合化学技术的研究与应用，包括诸如同步多重合成（混合固相合成）法、多头合成（多针合成）法、茶袋法、光印（光控合成）法、反应珠法、载体合成法、基因重组法、非肽类岸法、色谱条码法等及其检测方法。它们已成为寻找和发展分子多样性与研究开发新药的策略和途径。

Combinatorial chemistry is a novel technique for drug reseach and development,whichincludes two branches of conbinatorial synthesis and mass/library screening. The new meth-ods and related techniques were described,such as Peptide Library or Solid Multiple synthe-sis, Multipin synthesis, Teabag method. Optical print method/Optical controlled synthesis,Carrior-based synthesis, Reaction-ball method. Gene recombination techniques, Chro-matography-coded method,Non-peptide chemical library/NPNN library. These techniquesand/or methods became a new pathway for research and development of new drug.