左氧氟沙星注射液两种给药方法治疗老年院内获得性肺炎的临床分析

Clinical analysis of twe injected methods of levfloxacin in treatment of elderly patients with hospital acquired pneumonia

目的比较左氧氟沙星注射液两种给药方法治疗老年病区院内获得性肺炎(HAP)的有效性与安全性。方法56例老年HAP患者随机分为2组,治疗组(n=28)用左氧氟沙星注射液0.5g/次,1次/d;对照组(n=28)用注射用左氧氟沙星注射液0.3g,2次/d,疗程均为7～14d。结果治疗组和对照组的临床总有效率分别为85.7%和82.1%,细菌清除率分别为80.8%和80.0%,两组不良反应发生率分别为14.3%和17.9%。结论左氧氟沙星注射液两种给药方法治疗老年HAP疗效确切、不良反应少而轻微,可作为治疗老年患者院内获得性肺炎的一线用药。

Objective To compared the clinical efficacy and safety of twe injected methods of levofloxacin in treatment of elderly patients with hospital acquired pneumonia. Methods Fifty - eight elderly patients with hospital acquired pneumonia were divided into two groups in random.The therapy group was injected with levofloxacin 0.5g, qd;the control group was injected with levofloxacin 0.3g g, bid. Both courts of treatment were 7 -14 days. Results The total efficacy rates in the therapy and control groups were 85.7 % and 82.1%, respectively .The clearance rates of bacteria were 80.8% and 80.0% ,respectively. And the rates of side effects were 14.3% and 17.9%, respectively. Conclusions Twe injected methods of levofloxacin in treatment of elderly patients with HAP are effective and safe, it can be used as the first choice drug in the treatment of elderly patients with HAP.