奥氮平对首发精神分裂症患者的疗效及认知功能影响

Curative Effect of Olanzapine in Treating Patients with First-episode Schizophrenia and Its Impact on Cognition

目的观察奥氮平对首发精神分裂症患者的疗效及认知功能的影响。方法将31例首发精神分裂症患者经奥氮平治疗前及治疗12周后,用阳性症状量表(SAPS)、阴性症状量表(SANS)、韦氏成人智力量表(WAIS-R)、韦氏记忆量表(WMS)、简明精神症状评定量表(BPRS)、韦斯康星卡片分类测验(WCST)进行评估,观察奥氮平对精神分裂症症状的改变及对认知功能的影响。结果治疗后阳性症状、阴性症状量表、简明精神症状评定量表、韦斯康星卡片分类测验中错误应答数的评估分值显著降低(P<0.01),韦斯康星卡片分类测验中的非持续性错误、韦氏记忆量表中的再生、理解评估分值明显降低(P<0.05)。结论奥氮平治疗精神分裂症疗效可靠并可显著改善部分患者的认知功能。

Objective To observe the curative effect of olanzapine in treating patients with first - episode schizophrenia and its im- pact on cognition. Methodss 31 patients with first - episode schizophrenia were treated with olanzapine for 12 weeks; before and after treatment, SAPS, SANS, WAIS- R, WMS, BPRS and WCST were applied for evaluation, and the effect of olanzapine on symptom improve- ment and cognition was observed. Results After treatment,the evaluation scores of false answers in SAPS,SANS,BPRS and WCST decreased obviously （ P 〈 0.01 ） as well as the evaluation scores of nonpersistent mistakes in WCST and the evaluation scores of reactivation and comprehension in WMS （ P 〈 0.05}. Conclusions Olanzapine is effective in treating patients with first - episode schizophrenia and it can obviously improve the cognition of some patients.