山荷叶素醚类和苯甲酸酯类衍生物的合成

Synthesis of Ether and Arylacylester Derivatives of Diphyllin

合成了9种天然抗肿瘤活性萘基木质素山荷叶素的衍生物,通过威廉森醚化法合成了5种醚类衍生物,产率为76%~93%;通过DCC酯缩合法合成了4种苯甲酸酯类衍生物,产率为81%~85%,其结构分别采用1H NMR、13C NMR、HRMS及元素分析测试技术加以证实。

Nine derivatives of natural lignin diphyllin were synthesized. Five ether derivatives were synthe-sized via Williamson etherification with the yields of 76% ~ 93%. Four arylacylester derivatives of diphyllin were synthesized in the presence of DCC with the yields of 81% ~ 85%. These compounds were identified by 1H NMR, 13C NMR, HRMS and elemental analysis.