贲门癌TR6和survivin基因表达及其临床意义

Expression of TR6 and survivin gene in the tissue of cardiac cancer and its clinical significance

目的探讨诱骗受体3（DcR3／TR6）蛋白在贲门癌组织中表达的临床意义，及其与生存素蛋白（survivin）表达的相关性。方法采用二步法免疫组化技术（Envision），检测66例术前未经化疗的贲门癌组织中TR6和survivin基因的表达情况：结果66例贲门癌组织中TR6阳性表达36例，阳性率54．5％（36／66）；而survivin阳性率62．1％（41／66）.TR6表达与贲门癌组织学类型、临床分期和淋巴结转移有明显相关性（P〈0．05）；TR6在survivin阳性和阴性患者中阳性率分剐为73．2％（30／41）和24％（6／25），两者间差异有统计学意义（χ^2=15．15，P〈0．01）。结论TR6和survivin异常表达可促进贲门癌的发生发展，联合检测TR6和survivin基因，可作为判断贲门癌的分化程度、淋巴结转移及TNM分期的重要参考指标，也可为贲门癌临床诊治及判断预后提供客观依据及新的思路。

Objective To explore the clinical significance of expression of DcR3/TR6 gene in the tissue of cardiac cancer and its correlation with survivin gene expression. Methods Two-step immonohistochemistry technology was adopted to detect the expression of TR6 and survivin gene in 66 cases of cardiac cancer, none of＇ the patients received prior chemotherapy, Results The positive expression rate of TR6 and survivin genes in cardiac cancer was 54.5% and 62. 1% , respectively. The expression of TR6 was correlated with histolo~＇ type, clinical stage and lymph node metastasis of cardiac cancer （ P 〈 0.05 ）. The positive expression rate of TR6 in cases that cardiac cancer with survivin expressed was significant higher than those without surviving expressed （ χ^2 = 15. 145, P 〈 0. 01 ）. Conclusions The expression of TR6 and survivin can be regarded as valuable indicators for the diagnosis and prognosis of cardiac cancer.