新疆哈萨克族高血压人群的血管紧张素Ⅱ1型受体基因多态性与血脂水平的相关研究

The relationship between dyslipemia and the polymorphism of angiotensin Ⅱ type 1 receptor gene in hypertensive Kazakans of Xinjiang

目的探讨血管紧张素Ⅱ1型受体（AT1R）基因A1166C多态性与新疆哈萨克族原发性高血压（EH）人群血脂水平的关系。方法收集新疆哈萨克族EH患者296例及正常血压对照者198例遗传血液标本，采用多聚酶链式反应法及限制性片段长度多态性技术（PCR-RFLP）分析AT1R基因A1166C多态性，并用全自动生化检测仪测定所有研究对象的各项血脂生化指标。观察各组基因型及等位基因与血清血脂水平的关系。结果（1）总胆固醇（TC）和低密度脂蛋白胆固醇（LDL—C）水平在EH人群中高于正常对照人群[TC：（4．91±1．19）mmol／L对（4．43±1．20）mmol／L；LDL-C：（3．36±1．01）mmol／L对（2．94±1．30）mmol／L]，两者差异有统计学意义（P〈0．001）。（2）在EH人群中偏相关分析结果显示，TC和LDL—C水平与基因型存在着相关性，即AC基因型携带者TC和LDL—C水平高于AA基因型携带者。结论在新疆哈萨克族EH人群中TC和LDL—C水平与AT1R基因A1166C多态位点分子变异相关。

Objective To investigate the relationship between dyslipidemia and the polymorphism of angiotensin Ⅱ type 1 receptor （ATIR） gene A1166C in hypertensive Kazakans of Xinjiang area.Methods Polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） methods were used to detect the A1166C polymorphism of AT1R gene of 296 hypertensive and 198 normotensive Kazakans. Biochemical parameters were measured by autochemical emalyzer. Results （ 1 ） The TC and LDL-C levels are significantly higher in hypertension group than those in normotensive controls [ TC： （4. 91 ± 1.19 ）mmol/ L vs. （4.43 ± 1.20） mmol/L; LDL-C ： （3.36 ± 1.01 ） mmol/L vs. （ 2. 94 ± 1.30） mmol/L , P 〈 0. 001 ）. （ 2 ） In hypertension group, TC and LDL-C are related to A1166C polymorphism of AT1R gene and TC and LDL- C of AC carriers are significantly higher than AA carriers （ P 〈 0. 05 ）. Conclusion The dyslipidemia is related to A1166C polymorphism of AT1R gene in hypertensive Kazakans.