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遗传性QT延长综合征研究新进展 被引量：2

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摘要 遗传性QT延长综合征（LQTS）是一种家族遗传性电紊乱性心脏病，1957年由Jervell Lange—Nielsen首先发现并报道。临床主要表现为晕厥和猝死，心电图表现为QT间期延长、尖端扭转型室性心动过速（室速）。近10余年，随着分子生物学和循证医学研究的进展，LQTS的分子基因学和临床研究日新月异，本文综述了LQTS的基因诊断和临床研究的最新进展。
作者 刘金秋 高连君 杨延宗
机构地区 大连医科大学附属第一医院心内科
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2008年第10期954-956,共3页 Chinese Journal of Cardiology
关键词 遗传性QT延长综合征 尖端扭转型室性心动过速 QT间期延长 临床研究 LQTS 家族遗传性 心电图表现 分子生物学
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献26

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二级参考文献15

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共引文献13

同被引文献16

  • 1王鸿,耿丹明,李慧忠,涂学军.超声心动图对胎儿室上性心动过速的诊断及宫内治疗疗效评价[J].中华医学超声杂志（电子版）,2007,4(3):150-152. 被引量：9
  • 2姚维妙,黄荷凤.超声对胚胎及胎儿安全性研究新进展[J].国外医学（计划生育．生殖健康分册）,2006,25(3):147-150. 被引量：3
  • 3Yang Y, Yang Y, Liang B, et al. Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet, 2010; 86:827-880.
  • 4Schwartz PJ, Moss A J, Vincent GM, et al. Diagnostic criteria for the long QT syndrome: an update. Circulation, 1993;88:782-784.
  • 5Zhang L, Timothy KW, Vincent GM, et al. Spectrum of ST-T wave patterns and repolarization parameters in congenital long OT syndrome: ECG findings identify genotypes. Circulation, 2000; 102: 2-849.
  • 6Nemec J, Buneova M, Bulkova V, et al. Heart rate dependence of QT interval duration: differences among congenital long QT syndrome subtypes. J Cardiovasc Electrophysiol, 2004; 15:550-556.
  • 7Daubert JP, Zareba W, Rosero SZ, et. al. Role of implantable cardiovert defibrillator therapy in patients with long QT syndrome. Am Heart J, 2007;153:S53-58.
  • 8Goldenberg I, Horr S, Moss A J, et al. Risk of life-threatening cardiac events in patients with genotype-confirmed long QT syndrome and a normal range QTe. J Am Cardiol, 2011;57:51-59.
  • 9De Bruin ML, Pettersson M, Meyboom RH, et al. Anti-HERGactivity and the risk of drug-induced arrhythmias and suddendeath. Eur Heart J, 2005, 26(6) : 590-597.
  • 10Schwartz PJ, Stramba-Badiale M, Crotti L, et al. Prevalence ofthe congenital long-QT syndrome. Cirulation, 2009, 120 ( 18):1761-1767.

引证文献2

中华心血管病杂志
2008年 第10期

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