氟西汀和帕罗西汀治疗难治性肠易激综合征的比较

A clinical trial of fFluoxetine and Paroxetine for the treatment of the irritable bowel syndrome

目的比较氟西汀和帕罗西汀治疗肠易激综合征的疗效,并探讨抗抑郁药物的副反应。方法在常规消化内科治疗的基础上,分别采用氟西汀和帕罗西汀治疗114例顽固性肠易激综合征患者8周,评测其治疗前后症状变化。结果氟西汀组总有效率为79.7%;帕罗西汀组总有效率为83.6%。氟西汀引起失眠明显多于帕罗西汀;帕罗西汀引起乏力明显多于氟西汀。结论氟西汀和帕罗西汀均能改善肠易激综合征的症状,两者副反应无明显差别。

Objective To evaluate the effect of Fluoxetine and Paroxetine in the treatment of irritable bowel syndrome, and to study the side effect of antidepressive medicament. Methods As the routine treatment of digestive disease, a total of 114 patients with irritable bowel syndrome were randomly selected to receive the treatment with fiuoxetine and Paroxetine for 8 weeks. Results 79.7% of the patients successfully received the Iluoxetine treatment and 83.6% of the patients effectively received the Paroxetine treatment. The major side effect of fluoxetine is insomnia, and that of Paroxetine is tired. Concluedon Both the Fluoxetine and Paroxetine treatment help to improve the irritable bowel syndrome. There is no essential difference in the side effect of both antidepressive medicament.