紫外线减毒弓形虫对小鼠旋毛虫感染的影响

Immunization with UV-Attenuated Toxopalsma gondii Influences Infection of Trichinella spiralis in Mouse Model

目的探讨紫外线减毒弓形虫免疫对小鼠旋毛虫感染的影响。方法ICR小鼠分为两组,实验组为紫外线减毒弓形虫免疫3周后再感染旋毛虫,对照组为旋毛虫单独感染。结果与旋毛虫单感染相比,小鼠预先经紫外线减毒弓形虫免疫再感染旋毛虫,在感染后5～14d其小肠内的成虫数明显增加(肠道排虫明显延迟),而感染后23～90d其肌肉中的幼虫数明显下降。结论紫外线减毒弓形虫免疫对小鼠旋毛虫感染具有一定的免疫调节和异源性保护作用。

Objective To investigate the influence of UV-attenuated Toxoplasma gondii immunization on the infection of Trichinella spiralis in mouse models. Method Mice of experimental group were immunized with UVattenuated T. gondii, then infected with T. spiralis; mice infected with T. spiralis alone as control. Result Compared with control, there were significant higher adult worm burdens in the small intestine during 5-14 days post infection （delayed intestinal adult worm expulsion）, and lower muscular larval burdens during 23-90 days post infection, in mice immunized with UV-attenuated T. gondii. Conclusion Mice immunized with UV-attenuated T. gondii could change the course of T. spiralis infection, a significant heterologous protection from one parasite against the other.