流行性腮腺炎免疫后病例的流行病学特征

Analysis on Epidemiological and Pathogenic Characteristics of Post-Vaccination Mumps Cases

目的了解广州市流行性腮腺炎免疫后病例的流行病学特征,为进一步预防控制腮腺炎提供依据。方法对流行性腮腺炎病例进行流行病学个案调查,病例血清进行腮腺炎病毒的基因序列检测。结果178例调查对象中,82例有腮腺炎疫苗免疫接种史,其中接种1针次腮腺炎疫苗的80例(97.6%),接种2针次的2例(2.4%);接种腮腺炎疫苗后1年内发病的有4例,接种后2年内发病的有3例;免疫后阳性血清病毒SH基因测序结果与疫苗株(Jeryl-Lynn)100%同源性。免疫后病例与未免疫病例相比:不同年龄间的差异有显著性,出现免疫后病例发病高峰向后推移现象;性别和临床症状均无显著性差异。结论免疫后再感染的病例多数只接种过1针次腮腺炎疫苗;病毒基因与疫苗株同源,未发现变异;免疫后病例与未免疫相比发病年龄高峰向后推移。

Objective To understand the situation of mumps epidemic in Guangzhou city and epidemiological and pathogenic characteristics of post-vaccination in mumps cases. Method The mumps cases were investigated and SH gene of mumps virus strains were amplified and sequenced. Result In 178 mumps cases, there are 82 cases were vaccinated, accounted for 46.1%. There are no differences in sex and symptom between the vaccinated cases and the un-vaccinated cases. There is significant difference in age between the vaccinated cases and the un-vaccinated cases. The homology of SH gene between the mumps cases and vaccine strains （Jeryl-Lynn） was 100%. Conclusion The post-vaccination mumps cases were caused probably by the failure in vaccination. So the vaccine＇s storage and shipment is very important.